Non-Coding Transcript Heterogeneity in Mesothelioma: Insights from Asbestos-Exposed Mice

• Main Authors: Emanuela Felley-Bosco, Hubert Rehrauer
• Format: Article
• Language: English
• Published: MDPI AG 2018-04-01
• Series: International Journal of Molecular Sciences
• Subjects: mesothelioma heterogeneity; non-coding RNA; long-non-coding RNA
• Online Access: http://www.mdpi.com/1422-0067/19/4/1163

Mesothelioma is an aggressive, rapidly fatal cancer and a better understanding of its molecular heterogeneity may help with making more efficient therapeutic strategies. Non-coding RNAs represent a larger part of the transcriptome but their contribution to diseases is not fully understood yet. We used recently obtained RNA-seq data from asbestos-exposed mice and performed data mining of publicly available datasets in order to evaluate how non-coding RNA contribute to mesothelioma heterogeneity. Nine non-coding RNAs are specifically elevated in mesothelioma tumors and contribute to human mesothelioma heterogeneity. Because some of them have known oncogenic properties, this study supports the concept of non-coding RNAs as cancer progenitor genes.