Human Intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation

Human Intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation

Participates in actin remodeling through Rac and receptor endocytosisvia Rab5. Here, we used yeast two-hybrid systemwith Eps8 as bait to screen a human brain cDNA library.ITSN2 was identified as the novel binding factor of Eps8. Theinteraction between ITSN2 and Eps8 was demonstrated by thein vivo co...

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Bibliographic Details
Main Authors: Xiaofeng Ding, Zijian Yang, Fangliang Zhou, Xiang Hu, Chang Zhou, Chang Luo, Zhicheng He, Qian Liu, Hong Li, Feng Yan, Fangmei Wang, Shuanglin Xiang, Jian Zhang
Format: Article
Language:English
Published: Korean Society for Biochemistry and Molecular Biology 2012-03-01
Series:BMB Reports
Subjects:
Eps8
Interaction
ITSN2
Lysosome pathway
Protein degradation
Online Access:http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0zJTVEMTIwMzI3MTU0N18lMjgxODMtMTg4JTI5Qk1CXzExLTE5NS5wZGY=

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