Generation of neoantigen-specific T cells for adoptive cell transfer for treating head and neck squamous cell carcinoma

Generation of neoantigen-specific T cells for adoptive cell transfer for treating head and neck squamous cell carcinoma

Adoptive cell therapy using TCR-engineered T cells (TCR-T cells) represents a promising strategy for treating relapsed and metastatic cancers. We previously established methods to identify neoantigen-specific TCRs based on patients’ PBMCs. However, in clinical practice isolation of PBMCs from advanc...

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Bibliographic Details
Main Authors: Teng Wei, Matthias Leisegang, Ming Xia, Kazuma Kiyotani, Ning Li, Chenquan Zeng, Chunyan Deng, Jinxing Jiang, Makiko Harada, Nishant Agrawal, Liangping Li, Hui Qi, Yusuke Nakamura, Lili Ren
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
head and neck squamous cell carcinoma
adoptive t cell therapy
neoantigen
tumor-infiltrating lymphocytes
t cell receptor engineered t cells
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1929726

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