A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation

Lysozyme is an ubiquitous enzyme found in most biological secretions and leukocytes. This study was aimed at investigating its interaction with other inflammatory mediators on mucosa surfaces, particularly the complement system. Lysozyme has been shown in our present study, to inhibit the haemolytic...

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Main Author: M. O. Ogundele
Format: Article
Language:English
Published: Hindawi Limited 1998-01-01
Series:Mediators of Inflammation
Subjects:
Online Access:http://dx.doi.org/10.1080/09629359890893
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spelling doaj-9e9ac78907bf45ed93241ee5ee3668312020-11-24T22:38:08ZengHindawi LimitedMediators of Inflammation0962-93511466-18611998-01-017536336510.1080/09629359890893A novel anti-inflammatory activity of lysozyme: modulation of serum complement activationM. O. Ogundele0Department of Immunology, Georg-August University, Kreuzbergring 57, Göttingen D-37075, GermanyLysozyme is an ubiquitous enzyme found in most biological secretions and leukocytes. This study was aimed at investigating its interaction with other inflammatory mediators on mucosa surfaces, particularly the complement system. Lysozyme has been shown in our present study, to inhibit the haemolytic activity of serum complement in a dose-dependent fashion, when tested within the levels present in normal and inflamed breast-milk samples, and other mucosal secretions. This represents a new antiinflammatory action of lysozym e in relation to the serum complement, and the exact mode of the interaction need further studies.http://dx.doi.org/10.1080/09629359890893Human lysozymeComplement systemInflammation.
collection DOAJ
language English
format Article
sources DOAJ
author M. O. Ogundele
spellingShingle M. O. Ogundele
A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation
Mediators of Inflammation
Human lysozyme
Complement system
Inflammation.
author_facet M. O. Ogundele
author_sort M. O. Ogundele
title A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation
title_short A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation
title_full A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation
title_fullStr A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation
title_full_unstemmed A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation
title_sort novel anti-inflammatory activity of lysozyme: modulation of serum complement activation
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 1998-01-01
description Lysozyme is an ubiquitous enzyme found in most biological secretions and leukocytes. This study was aimed at investigating its interaction with other inflammatory mediators on mucosa surfaces, particularly the complement system. Lysozyme has been shown in our present study, to inhibit the haemolytic activity of serum complement in a dose-dependent fashion, when tested within the levels present in normal and inflamed breast-milk samples, and other mucosal secretions. This represents a new antiinflammatory action of lysozym e in relation to the serum complement, and the exact mode of the interaction need further studies.
topic Human lysozyme
Complement system
Inflammation.
url http://dx.doi.org/10.1080/09629359890893
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