Exploring the Interaction of Curaxin CBL0137 with G-Quadruplex DNA Oligomers

Exploring the Interaction of Curaxin CBL0137 with G-Quadruplex DNA Oligomers

Curaxins and especially the second-generation derivative curaxin CBL0137 have important antitumor activities in multiple cancers such as glioblastoma, melanoma and others. Although most of the authors suggest that their mechanism of action comes from the activation of p53 and inactivation of NF-kB b...

Full description

Bibliographic Details
Main Authors:	Sabrina Dallavalle, Luce M. Mattio, Roberto Artali, Loana Musso, Anna Aviñó, Carme Fàbrega, Ramon Eritja, Raimundo Gargallo, Stefania Mazzini
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	International Journal of Molecular Sciences
Subjects:	curaxin NMR spectroscopy circular dichroism G-quadruplex molecular modeling DNA interactions
Online Access:	https://www.mdpi.com/1422-0067/22/12/6476

Similar Items

Antitumor effect of the curaxin CBL0137 on the models of colon cancer
by: T. I. Fetisov, et al.
Published: (2016-09-01)

Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation
by: Maxime J. Jean, et al.
Published: (2017-10-01)

Investigation of the Complexes Formed between PARP1 Inhibitors and PARP1 G-Quadruplex at the Gene Promoter Region
by: Sabrina Dallavalle, et al.
Published: (2021-08-01)

Curaxin CBL0137 Exerts Anticancer Activity via Diverse Mechanisms
by: Ming-Zhu Jin, et al.
Published: (2018-12-01)

Tuning G-Quadruplex Nanostructures with Lipids. Towards Designing Hybrid Scaffolds for Oligonucleotide Delivery
by: Santiago Grijalvo, et al.
Published: (2021-12-01)

Conformational dynamics of G-quadruplex DNA probed by time-resolved circular dichroism
by: Schmid, Marco
Published: (2017)

Stabilization of c-KIT G-Quadruplex DNA Structures by the RNA Polymerase I Inhibitors BMH-21 and BA-41
by: Stefania Mazzini, et al.
Published: (2019-10-01)

Conformation of G-quadruplex Controlled by Click Reaction
by: Chao-Da Xiao, et al.
Published: (2020-09-01)

Recurrent Potential G-Quadruplex Sequences in Archaeal Genomes
by: Galina V. Chashchina, et al.
Published: (2021-03-01)

Parallel G-quadruplex Structures Increase Cellular Uptake and Cytotoxicity of 5-Fluoro-2′-deoxyuridine Oligomers in 5-Fluorouracil Resistant Cells
by: Anna Clua, et al.
Published: (2021-03-01)

Selective Recognition of Quadruplex DNA by Small Molecules
by: White, Elizabeth W.
Published: (2006)

Importance of Chiral Recognition in Designing Metal-Free Ligands for G-Quadruplex DNA
by: Dora M. Răsădean, et al.
Published: (2019-04-01)

Diversity of Parallel Guanine Quadruplexes Induced by Guanine Substitutions
by: Klára Bednářová, et al.
Published: (2020-08-01)

G4 Matters—The Influence of G-Quadruplex Structural Elements on the Antiproliferative Properties of G-Rich Oligonucleotides
by: Carolina Roxo, et al.
Published: (2021-05-01)

G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide
by: Sabrina Dallavalle, et al.
Published: (2021-02-01)

Targeting G-quadruplexes with Organic Dyes: Chelerythrine–DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy
by: Alessio Terenzi, et al.
Published: (2019-10-01)

TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells
by: Katerina Leonova, et al.
Published: (2018-02-01)

Heterocyclic Cations as Potential Anticancer Agents: An Approach that Targets G-quadruplex with Different Binding Modes
by: Musetti, Caterina Livia
Published: (2010)

Solvent Vibrations as a Proxy of the Telomere G-Quadruplex Rearrangements across Thermal Unfolding
by: Bianchi, F., et al.
Published: (2022)

Cyanine Dyes Targeting G-quadruplex DNA: Significance in Sequence and Conformation Selectivity
by: Huynh, Hang T
Published: (2015)

Oxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Binding
by: Filippo Doria, et al.
Published: (2018-08-01)

Quadruplex DNA in long terminal repeats in maize LTR retrotransposons inhibits the expression of a reporter gene in yeast
by: Viktor Tokan, et al.
Published: (2018-03-01)

Structural and Affinity Analyses of G-Quadruplex DNA Aptamers for Camptothecin Derivatives
by: Naoki Sugimoto, et al.
Published: (2013-08-01)

The Human Telomere Sequence, (TTAGGG)4, in the Absence and Presence of Cosolutes: A Spectroscopic Investigation
by: Vishal R. Sharma, et al.
Published: (2014-01-01)

Modulation of Aptamer–Ligand-Binding by Complementary Oligonucleotides: A G-Quadruplex Anti-Ochratoxin A Aptamer Case Study
by: Bonchuk, A.N, et al.
Published: (2022)

DNA and RNA Quadruplex-Binding Proteins
by: Václav Brázda, et al.
Published: (2014-09-01)

Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers
by: Rubén Ferreira, et al.
Published: (2010-01-01)

Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex
by: Rabindra Nath Das, et al.
Published: (2017-12-01)

Multicharged Phthalocyanines as Selective Ligands for G-Quadruplex DNA Structures
by: Catarina I. V. Ramos, et al.
Published: (2019-02-01)

Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents
by: Pallavi Chilka, et al.
Published: (2019-02-01)

G-Quadruplexes as Sensing Probes
by: Branislav Ruttkay-Nedecky, et al.
Published: (2013-11-01)

Cyanine Dye Interactions with Quadruplex and Duplex DNA: Changes in Conformation, Stability, and Affinity
by: Mickelson, Leah E
Published: (2011)

Macrocyclic Pyridyl Polyoxazoles: Structure-Activity Studies of the Aminoalkyl Side-Chain on G-Quadruplex Stabilization and Cytotoxic Activity
by: Joseph E. Rice, et al.
Published: (2013-09-01)

An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer
by: Victoria Sanchez-Martin, et al.
Published: (2020-11-01)

G-Quadruplexes at Telomeres: Friend or Foe?
by: Tracy M. Bryan
Published: (2020-08-01)

Quadruplex Ligands in Cancer Therapy
by: Victoria Sanchez-Martin, et al.
Published: (2021-06-01)

The Targeting of Quadruplex Nucleic Acids in Human Cancers
by: Stephen Neidle
Published: (2019-08-01)

Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
by: Zhi-Yin Sun, et al.
Published: (2019-01-01)

Genetic interactions of G-quadruplexes in humans
by: Katherine G Zyner, et al.
Published: (2019-07-01)

Beyond G-Quadruplexes—The Effect of Junction with Additional Structural Motifs on Aptamers Properties
by: Weronika Kotkowiak, et al.
Published: (2021-09-01)