Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity

Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity

Dendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. All these processes take place under conditions of oxygen shortage (hypo...

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Main Authors: Sandra Winning, Joachim Fandrey
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2016/5134329
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spelling doaj-9e938c5101574fa18ff96b1ac8c79fe42020-11-24T21:03:06ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/51343295134329Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive ImmunitySandra Winning0Joachim Fandrey1Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, GermanyInstitut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, GermanyDendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. All these processes take place under conditions of oxygen shortage (hypoxia) which is often not considered in experimental settings. This review highlights how deeply hypoxia modulates human as well as mouse immature and mature dendritic cell functions. It tries to link in vitro results to actual in vivo studies and outlines how hypoxia-mediated shaping of dendritic cells affects the activation of (innate) immunity.http://dx.doi.org/10.1155/2016/5134329
collection DOAJ
language English
format Article
sources DOAJ
author Sandra Winning
Joachim Fandrey
spellingShingle Sandra Winning
Joachim Fandrey
Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity
Journal of Immunology Research
author_facet Sandra Winning
Joachim Fandrey
author_sort Sandra Winning
title Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity
title_short Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity
title_full Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity
title_fullStr Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity
title_full_unstemmed Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity
title_sort dendritic cells under hypoxia: how oxygen shortage affects the linkage between innate and adaptive immunity
publisher Hindawi Limited
series Journal of Immunology Research
issn 2314-8861
2314-7156
publishDate 2016-01-01
description Dendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. All these processes take place under conditions of oxygen shortage (hypoxia) which is often not considered in experimental settings. This review highlights how deeply hypoxia modulates human as well as mouse immature and mature dendritic cell functions. It tries to link in vitro results to actual in vivo studies and outlines how hypoxia-mediated shaping of dendritic cells affects the activation of (innate) immunity.
url http://dx.doi.org/10.1155/2016/5134329
work_keys_str_mv AT sandrawinning dendriticcellsunderhypoxiahowoxygenshortageaffectsthelinkagebetweeninnateandadaptiveimmunity
AT joachimfandrey dendriticcellsunderhypoxiahowoxygenshortageaffectsthelinkagebetweeninnateandadaptiveimmunity
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