Frequent alteration of the tumor suppressor gene APC in sporadic canine colorectal tumors.

Frequent alteration of the tumor suppressor gene APC in sporadic canine colorectal tumors.

Sporadic canine colorectal cancers (CRCs) should make excellent models for studying the corresponding human cancers. To molecularly characterize canine CRC, we investigated exonic sequence mutations of adenomatous polyposis coli (APC), the best known tumor suppressor gene of human CRC, in 23 sporadi...

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Bibliographic Details
Main Authors: Lydia Youmans, Cynthia Taylor, Edwin Shin, Adrienne Harrell, Angela E Ellis, Bernard Séguin, Xinglai Ji, Shaying Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3519478?pdf=render

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