Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung Cancer

Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung Cancer

This study presented the analysis of free-breathing lung tumor motion characteristics using GE 4DCT and Varian RPM systems. Tumor respiratory movement was found to be associated with GTV size, the superior-inferior tumor location in the lung, and the attachment degree to rigid structure (e.g., chest...

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Main Authors: Yan Wang, Yong Bao, Li Zhang, Wei Fan, Han He, Zong-Wen Sun, Xiao Hu, Shao-Min Huang, Ming Chen, Xiao-Wu Deng
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/872739
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spelling doaj-9e85fdc2148c423db7b36eb6882d16e72020-11-24T22:38:44ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/872739872739Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung CancerYan Wang0Yong Bao1Li Zhang2Wei Fan3Han He4Zong-Wen Sun5Xiao Hu6Shao-Min Huang7Ming Chen8Xiao-Wu Deng9Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, ChinaDepartment of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, ChinaDepartment of Radiation Physics, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaDepartment of Nuclear Physics, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaDepartment of Radiation Oncology, The First People’s Hospital of Foshan City, Foshan 528800, ChinaDepartment of Radiation Oncology, The First People’s Hospital of Jining City, Jining 272011, ChinaDepartment of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, ChinaDepartment of Radiation Physics, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaDepartment of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, ChinaDepartment of Radiation Physics, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaThis study presented the analysis of free-breathing lung tumor motion characteristics using GE 4DCT and Varian RPM systems. Tumor respiratory movement was found to be associated with GTV size, the superior-inferior tumor location in the lung, and the attachment degree to rigid structure (e.g., chest wall, vertebrae, or mediastinum), with tumor location being the most important factor among the other two. Improved outcomes in survival and local control of 43 lung cancer patients were also reported. Consideration of respiration-induced motion based on 4DCT for lung cancer yields individualized margin and more accurate and safe target coverage and thus can potentially improve treatment outcome.http://dx.doi.org/10.1155/2013/872739
collection DOAJ
language English
format Article
sources DOAJ
author Yan Wang
Yong Bao
Li Zhang
Wei Fan
Han He
Zong-Wen Sun
Xiao Hu
Shao-Min Huang
Ming Chen
Xiao-Wu Deng
spellingShingle Yan Wang
Yong Bao
Li Zhang
Wei Fan
Han He
Zong-Wen Sun
Xiao Hu
Shao-Min Huang
Ming Chen
Xiao-Wu Deng
Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung Cancer
BioMed Research International
author_facet Yan Wang
Yong Bao
Li Zhang
Wei Fan
Han He
Zong-Wen Sun
Xiao Hu
Shao-Min Huang
Ming Chen
Xiao-Wu Deng
author_sort Yan Wang
title Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung Cancer
title_short Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung Cancer
title_full Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung Cancer
title_fullStr Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung Cancer
title_full_unstemmed Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung Cancer
title_sort assessment of respiration-induced motion and its impact on treatment outcome for lung cancer
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description This study presented the analysis of free-breathing lung tumor motion characteristics using GE 4DCT and Varian RPM systems. Tumor respiratory movement was found to be associated with GTV size, the superior-inferior tumor location in the lung, and the attachment degree to rigid structure (e.g., chest wall, vertebrae, or mediastinum), with tumor location being the most important factor among the other two. Improved outcomes in survival and local control of 43 lung cancer patients were also reported. Consideration of respiration-induced motion based on 4DCT for lung cancer yields individualized margin and more accurate and safe target coverage and thus can potentially improve treatment outcome.
url http://dx.doi.org/10.1155/2013/872739
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AT lizhang assessmentofrespirationinducedmotionanditsimpactontreatmentoutcomeforlungcancer
AT weifan assessmentofrespirationinducedmotionanditsimpactontreatmentoutcomeforlungcancer
AT hanhe assessmentofrespirationinducedmotionanditsimpactontreatmentoutcomeforlungcancer
AT zongwensun assessmentofrespirationinducedmotionanditsimpactontreatmentoutcomeforlungcancer
AT xiaohu assessmentofrespirationinducedmotionanditsimpactontreatmentoutcomeforlungcancer
AT shaominhuang assessmentofrespirationinducedmotionanditsimpactontreatmentoutcomeforlungcancer
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