Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent

We present the rare case of a fatal anaphylactic reaction to gadobutrol, a magnetic resonance imaging contrast agent, in a 42-year-old man. The patient underwent elective magnetic resonance imaging for diagnostic clarification of a suspicious finding in the abdomen. The patient had undergone contras...

Full description

Bibliographic Details
Main Authors:	Sabine Franckenberg, MD, Florian Berger, MD, Sarah Schaerli, MD, Garyfalia Ampanozi, MD, Michael Thali, Prof., MD, Executive MBA HSG
Format:	Article
Language:	English
Published:	Elsevier 2018-02-01
Series:	Radiology Case Reports
Subjects:	Gadobutrol Gadolinium Anaphylactic reaction MRI
Online Access:	http://www.sciencedirect.com/science/article/pii/S1930043317303667

id	doaj-9e6f7b72cba24c73bf0536e93fe8c1ab
record_format	Article
spelling	doaj-9e6f7b72cba24c73bf0536e93fe8c1ab2020-11-24T22:42:54ZengElsevierRadiology Case Reports1930-04332018-02-0113129930110.1016/j.radcr.2017.09.012Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agentSabine Franckenberg, MD0Florian Berger, MD1Sarah Schaerli, MD2Garyfalia Ampanozi, MD3Michael Thali, Prof., MD, Executive MBA HSG4Institute of Diagnostic and Interventional Radiology, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, SwitzerlandInstitute of Forensic Medicine, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Forensic Medicine, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Forensic Medicine, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Forensic Medicine, University of Zurich, 8057 Zurich, SwitzerlandWe present the rare case of a fatal anaphylactic reaction to gadobutrol, a magnetic resonance imaging contrast agent, in a 42-year-old man. The patient underwent elective magnetic resonance imaging for diagnostic clarification of a suspicious finding in the abdomen. The patient had undergone contrast-enhanced computed tomography previously without the occurrence of any adverse effects. Adverse drug reactions in gadobutrol have a very low prevalence of 0.32%-3.5%, with serious adverse drug reactions in <0.1%. There are only a few cases of fatal anaphylactoid reactions to gadolinium-based contrast agents in general. However, if an anaphylactoid reaction occurs, it can present itself with a fulminant course within minutes.http://www.sciencedirect.com/science/article/pii/S1930043317303667GadobutrolGadoliniumAnaphylactic reactionMRI
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sabine Franckenberg, MD Florian Berger, MD Sarah Schaerli, MD Garyfalia Ampanozi, MD Michael Thali, Prof., MD, Executive MBA HSG
spellingShingle	Sabine Franckenberg, MD Florian Berger, MD Sarah Schaerli, MD Garyfalia Ampanozi, MD Michael Thali, Prof., MD, Executive MBA HSG Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent Radiology Case Reports Gadobutrol Gadolinium Anaphylactic reaction MRI
author_facet	Sabine Franckenberg, MD Florian Berger, MD Sarah Schaerli, MD Garyfalia Ampanozi, MD Michael Thali, Prof., MD, Executive MBA HSG
author_sort	Sabine Franckenberg, MD
title	Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent
title_short	Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent
title_full	Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent
title_fullStr	Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent
title_full_unstemmed	Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent
title_sort	fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based mri contrast agent
publisher	Elsevier
series	Radiology Case Reports
issn	1930-0433
publishDate	2018-02-01
description	We present the rare case of a fatal anaphylactic reaction to gadobutrol, a magnetic resonance imaging contrast agent, in a 42-year-old man. The patient underwent elective magnetic resonance imaging for diagnostic clarification of a suspicious finding in the abdomen. The patient had undergone contrast-enhanced computed tomography previously without the occurrence of any adverse effects. Adverse drug reactions in gadobutrol have a very low prevalence of 0.32%-3.5%, with serious adverse drug reactions in <0.1%. There are only a few cases of fatal anaphylactoid reactions to gadolinium-based contrast agents in general. However, if an anaphylactoid reaction occurs, it can present itself with a fulminant course within minutes.
topic	Gadobutrol Gadolinium Anaphylactic reaction MRI
url	http://www.sciencedirect.com/science/article/pii/S1930043317303667
work_keys_str_mv	AT sabinefranckenbergmd fatalanaphylacticreactiontointravenousgadobutrolagadoliniumbasedmricontrastagent AT florianbergermd fatalanaphylacticreactiontointravenousgadobutrolagadoliniumbasedmricontrastagent AT sarahschaerlimd fatalanaphylacticreactiontointravenousgadobutrolagadoliniumbasedmricontrastagent AT garyfaliaampanozimd fatalanaphylacticreactiontointravenousgadobutrolagadoliniumbasedmricontrastagent AT michaelthaliprofmdexecutivembahsg fatalanaphylacticreactiontointravenousgadobutrolagadoliniumbasedmricontrastagent
_version_	1725697942089629696

Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent

Similar Items