Mutation Screening of the GLE1 Gene in a Large Chinese Cohort of Amyotrophic Lateral Sclerosis Patients

Mutation Screening of the GLE1 Gene in a Large Chinese Cohort of Amyotrophic Lateral Sclerosis Patients

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease involving the upper and lower motor neurons of the spinal cord, brainstem, and cerebral cortex. At least 30 genes have been implicated in familial ALS (fALS) and sporadic ALS (sALS). Kaneb et al. (2015) first carrie...

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Bibliographic Details
Main Authors: Yanran Li, Bo Sun, Zhanjun Wang, Zhengqing He, Fei Yang, Hongfen Wang, Fang Cui, Zhaohui Chen, Li Ling, Chaodong Wang, Xusheng Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis
GLE1
loss-of-function mutation
OPTN
oligogenic inheritance of ALS
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.595775/full

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