Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis
Abstract Background Due to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological disorders such as multiple sclerosis (MS) are largely unknown. In that context, profiling DNA methylation, which is a stable and cell type-specific regulatory epigene...
Main Authors: | Lara Kular, Maria Needhamsen, Milena Z. Adzemovic, Tatiana Kramarova, David Gomez-Cabrero, Ewoud Ewing, Eliane Piket, Jesper Tegnér, Stephan Beck, Fredrik Piehl, Lou Brundin, Maja Jagodic |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-05-01
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Series: | Clinical Epigenetics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13148-019-0678-1 |
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