No strings attached: new insights into epithelial morphogenesis

No strings attached: new insights into epithelial morphogenesis

<p>Abstract</p> <p>The dramatic ingression of tissue sheets that accompanies many morphogenetic processes, most notably gastrulation, has been largely attributed to contractile circum-apical actomyosin 'purse-strings' in the infolding cells. Recent studies, however, inclu...

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Main Author: Davidson Lance A
Format: Article
Language:English
Published: BMC 2012-12-01
Series:BMC Biology
Online Access:http://www.biomedcentral.com/1741-7007/10/105
id doaj-9e5e3bb769784b3ebe1a6d94342cf5ef
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spelling doaj-9e5e3bb769784b3ebe1a6d94342cf5ef2020-11-24T21:17:06ZengBMCBMC Biology1741-70072012-12-0110110510.1186/1741-7007-10-105No strings attached: new insights into epithelial morphogenesisDavidson Lance A<p>Abstract</p> <p>The dramatic ingression of tissue sheets that accompanies many morphogenetic processes, most notably gastrulation, has been largely attributed to contractile circum-apical actomyosin 'purse-strings' in the infolding cells. Recent studies, however, including one in <it>BMC Biology</it>, expose mechanisms that rely less on actomyosin contractility of purse-string bundles and more on dynamics in the global cortical actomyosin network of the cells. These studies illustrate how punctuated actomyosin contractions and flow of these networks can remodel both epithelial and planarly organized mesenchymal sheets.</p> http://www.biomedcentral.com/1741-7007/10/105
collection DOAJ
language English
format Article
sources DOAJ
author Davidson Lance A
spellingShingle Davidson Lance A
No strings attached: new insights into epithelial morphogenesis
BMC Biology
author_facet Davidson Lance A
author_sort Davidson Lance A
title No strings attached: new insights into epithelial morphogenesis
title_short No strings attached: new insights into epithelial morphogenesis
title_full No strings attached: new insights into epithelial morphogenesis
title_fullStr No strings attached: new insights into epithelial morphogenesis
title_full_unstemmed No strings attached: new insights into epithelial morphogenesis
title_sort no strings attached: new insights into epithelial morphogenesis
publisher BMC
series BMC Biology
issn 1741-7007
publishDate 2012-12-01
description <p>Abstract</p> <p>The dramatic ingression of tissue sheets that accompanies many morphogenetic processes, most notably gastrulation, has been largely attributed to contractile circum-apical actomyosin 'purse-strings' in the infolding cells. Recent studies, however, including one in <it>BMC Biology</it>, expose mechanisms that rely less on actomyosin contractility of purse-string bundles and more on dynamics in the global cortical actomyosin network of the cells. These studies illustrate how punctuated actomyosin contractions and flow of these networks can remodel both epithelial and planarly organized mesenchymal sheets.</p>
url http://www.biomedcentral.com/1741-7007/10/105
work_keys_str_mv AT davidsonlancea nostringsattachednewinsightsintoepithelialmorphogenesis
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