Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation

Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation

This study revealed the microbial compositions in children with bacterial meningitis who were treated with antibiotics and made a comprehensive comparison between blood and CSF specimens for risk and prognosis assessment. We found that microbiome signatures could distinguish patient subsets and wer...

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Main Authors: Huiping Liao, Yuchao Zhang, Wei Guo, Xi Wang, Hailong Wang, Haocheng Ye, Kai Wu, Yu-Hang Zhang, Lingyun Guo, Yufei Zhu, Yongli Guo, Landian Hu, Gang Liu, Xiangyin Kong
Format: Article
Language:English
Published: American Society for Microbiology 2021-06-01
Series:mSystems
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00049-21
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spelling doaj-9e53c87cdad3470587c8c34c02f500c92021-09-21T18:52:39ZengAmerican Society for MicrobiologymSystems2379-50772021-06-016310.1128/mSystems.00049-21Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with InflammationHuiping Liao0https://orcid.org/0000-0002-3688-8967Yuchao Zhang1Wei Guo2Xi Wang3Hailong Wang4Haocheng Ye5Kai Wu6Yu-Hang Zhang7Lingyun Guo8Yufei Zhu9Yongli Guo10Landian Hu11Gang Liu12Xiangyin Kong13Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaKey Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaKey Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaKey Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaKey Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaKey Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China This study revealed the microbial compositions in children with bacterial meningitis who were treated with antibiotics and made a comprehensive comparison between blood and CSF specimens for risk and prognosis assessment. We found that microbiome signatures could distinguish patient subsets and were correlated with the CRP level in blood and granulocyte percentage in CSF.https://journals.asm.org/doi/10.1128/mSystems.00049-21
collection DOAJ
language English
format Article
sources DOAJ
author Huiping Liao
Yuchao Zhang
Wei Guo
Xi Wang
Hailong Wang
Haocheng Ye
Kai Wu
Yu-Hang Zhang
Lingyun Guo
Yufei Zhu
Yongli Guo
Landian Hu
Gang Liu
Xiangyin Kong
spellingShingle Huiping Liao
Yuchao Zhang
Wei Guo
Xi Wang
Hailong Wang
Haocheng Ye
Kai Wu
Yu-Hang Zhang
Lingyun Guo
Yufei Zhu
Yongli Guo
Landian Hu
Gang Liu
Xiangyin Kong
Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation
mSystems
author_facet Huiping Liao
Yuchao Zhang
Wei Guo
Xi Wang
Hailong Wang
Haocheng Ye
Kai Wu
Yu-Hang Zhang
Lingyun Guo
Yufei Zhu
Yongli Guo
Landian Hu
Gang Liu
Xiangyin Kong
author_sort Huiping Liao
title Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation
title_short Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation
title_full Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation
title_fullStr Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation
title_full_unstemmed Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation
title_sort characterization of the blood and cerebrospinal fluid microbiome in children with bacterial meningitis and its potential correlation with inflammation
publisher American Society for Microbiology
series mSystems
issn 2379-5077
publishDate 2021-06-01
description This study revealed the microbial compositions in children with bacterial meningitis who were treated with antibiotics and made a comprehensive comparison between blood and CSF specimens for risk and prognosis assessment. We found that microbiome signatures could distinguish patient subsets and were correlated with the CRP level in blood and granulocyte percentage in CSF.
url https://journals.asm.org/doi/10.1128/mSystems.00049-21
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