2-methoxyestradiol induces vasodilation by stimulating NO release via PPARγ/PI3K/Akt pathway.

2-methoxyestradiol induces vasodilation by stimulating NO release via PPARγ/PI3K/Akt pathway.

The endogenous estradiol metabolite 2-methoxyestradiol (2-ME) reduces atherosclerotic lesion formation, while the underlying mechanisms remain obscure. In this work, we investigated the vasodilatory effect of 2-ME and the role of nitric oxide (NO) involved. In vivo studies using noninvasive tail-cuf...

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Bibliographic Details
Main Authors: Weiyu Chen, Yuhong Cui, Shuhui Zheng, Jinghe Huang, Ping Li, Tommaso Simoncini, Yongfu Zhang, Xiaodong Fu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4351983?pdf=render

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