A 8-mer Peptide of PGLYRP1/Tag7 Innate Immunity Protein Binds to TNFR1 Receptor and Inhibits TNFα-Induced Cytotoxic Effect and Inflammation

A 8-mer Peptide of PGLYRP1/Tag7 Innate Immunity Protein Binds to TNFR1 Receptor and Inhibits TNFα-Induced Cytotoxic Effect and Inflammation

Search for novel regulatory protein fragments with potential functional roles is required both for understanding the immune response mechanisms and the development of targeted immunotherapy. Earlier we demonstrated that the PGLYRP1/Tag7 innate immunity protein can be regarded as an inhibitor of TNFα...

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Bibliographic Details
Main Authors: Georgii B. Telegin, Aleksandr S. Chernov, Vitaly A. Kazakov, Elena A. Romanova, Tatiana N. Sharapova, Denis V. Yashin, Alexander G. Gabibov, Lidia P. Sashchenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
mice
complete Freund’s adjuvant
inflammation
arthritis
TNFα
Tag7
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.622471/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.622471/full

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