Effect of allopurinol combined with Tongfengding capsule on inflammatory factors, hepatorenal functions and related indicators in gouty patients

• Main Author: Li Tang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-11-01
• Series: Journal of Hainan Medical University
• Subjects: Allopurinol; Tongfengding capsule; Gout; Combined treatment; Hypeluricemia
• Online Access: http://www.hnykdxxb.com/PDF/201621/14.pdf

Objective: To observe the effects of allopurinol combined with Tongfengding capsule on inflammatory factors, hepatorenal functions and the related indicators in gouty patients, for helping clinical treatment of gouty patients. Methods: A total of 180 gouty patients in our hospital were selected and randomly divided into observation group and control group, 90 cases in each group. Control group was treated with conventional therapy and allopurinol therapy, observation group was treated with allopurinol combined with Tongfengding capsule based on conventional therapy, the changes of inflammatory factors, hepatorenal functions and the related indicators were detected before and after treatment. Results: The difference of inflammatory factors, hepatorenal functions and the related indicators in the two groups before treatment was not statistically significant (P>0.05). Inflammatory factors (IL-6, IL-8, TNF-α and CRP), hepatorenal functions (ALT, AST, BUN and Cr) and gout related indicators (ESR, UA, 24 h urine protein and XOD) in observation group after treatment significantly decreased compared with that before treatment. Inflammatory factors, hepatorenal functions and gout related indicators in control group after treatment significantly decreased (P<0.05). Inflammatory factors, hepatorenal functions and gout related indicators in observation group after treatment decreased more significantly than that in control group (P<0.05). Conclusions: Allopurinol combined with Tongfengding capsule could improve inflammatory factors, hepatorenal functions and the related indicators in gouty patients, and help clinical treatment of gouty patients.