Nucleotide-Induced Conformational Changes in Escherichia coli DnaA Protein Are Required for Bacterial ORC to Pre-RC Conversion at the Chromosomal Origin

Nucleotide-Induced Conformational Changes in Escherichia coli DnaA Protein Are Required for Bacterial ORC to Pre-RC Conversion at the Chromosomal Origin

DnaA oligomerizes when bound to origins of chromosomal replication. Structural analysis of a truncated form of DnaA from Aquifex aeolicus has provided insight into crucial conformational differences within the AAA+ domain that are specific to the ATP- versus ADP- bound form of DnaA. In this study mo...

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Bibliographic Details
Main Authors: Rahul Saxena, Sona Vasudevan, Digvijay Patil, Norah Ashoura, Julia E. Grimwade, Elliott Crooke
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:International Journal of Molecular Sciences
Subjects:
DnaA protein
AAA+ domain
molecular docking
proteolysis
chromosomal origin
DNA replication
Online Access:http://www.mdpi.com/1422-0067/16/11/26064

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