Intravenously administered alphavirus vector VA7 eradicates orthotopic human glioma xenografts in nude mice.

Intravenously administered alphavirus vector VA7 eradicates orthotopic human glioma xenografts in nude mice.

VA7 is a neurotropic alphavirus vector based on an attenuated strain of Semliki Forest virus. We have previously shown that VA7 exhibits oncolytic activity against human melanoma xenografts in immunodeficient mice. The purpose of this study was to determine if intravenously administered VA7 would be...

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Bibliographic Details
Main Authors: Jari E Heikkilä, Markus J V Vähä-Koskela, Janne J Ruotsalainen, Miika W Martikainen, Marianne M Stanford, J Andrea McCart, John C Bell, Ari E Hinkkanen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2799335?pdf=render

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