Autocrine Transforming Growth Factor-β Growth Pathway in Murine Osteosarcoma Cell Lines Associated with Inability to Affect Phosphorylation of Retinoblastoma Protein

Purpose. Production of active transforming growth factor-β (TGF-β ) by human osteosarcoma may contribute to malignant progression through mechanisms that include induction of angiogenesis, immune suppression and autocrine growth stimulation of tumor cell growth.To...

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Bibliographic Details
Main Authors: Fariba Navid, John J. Letterio, Choh L. Yeung, Michiel Pegtel, Lee J. Helman
Format: Article
Language:English
Published: Hindawi Limited 2000-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1080/13577140020008057

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