Autocrine Transforming Growth Factor-β Growth Pathway in Murine Osteosarcoma Cell Lines Associated with Inability to Affect Phosphorylation of Retinoblastoma Protein
Purpose. Production of active transforming growth factor-β (TGF-β ) by human osteosarcoma may contribute to malignant progression through mechanisms that include induction of angiogenesis, immune suppression and autocrine growth stimulation of tumor cell growth.To...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2000-01-01
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| Series: | Sarcoma |
| Online Access: | http://dx.doi.org/10.1080/13577140020008057 |
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doaj-9e3c679dd6524ff4b8202d563074e4b82020-11-24T21:07:21ZengHindawi LimitedSarcoma1357-714X1369-16432000-01-01439310210.1080/13577140020008057Autocrine Transforming Growth Factor-β Growth Pathway in Murine Osteosarcoma Cell Lines Associated with Inability to Affect Phosphorylation of Retinoblastoma ProteinFariba Navid0John J. Letterio1Choh L. Yeung2Michiel Pegtel3Lee J. Helman4Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USALaboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USAPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USALaboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USAPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda 20892-1928, MD, USAPurpose. Production of active transforming growth factor-β (TGF-β ) by human osteosarcoma may contribute to malignant progression through mechanisms that include induction of angiogenesis, immune suppression and autocrine growth stimulation of tumor cell growth.To study events associated with induction of cell proliferation by TGF-β , we have evaluated the TGF-β pathway in two murine osteosarcoma cell lines, K7 and K12.http://dx.doi.org/10.1080/13577140020008057 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Fariba Navid John J. Letterio Choh L. Yeung Michiel Pegtel Lee J. Helman |
| spellingShingle |
Fariba Navid John J. Letterio Choh L. Yeung Michiel Pegtel Lee J. Helman Autocrine Transforming Growth Factor-β Growth Pathway in Murine Osteosarcoma Cell Lines Associated with Inability to Affect Phosphorylation of Retinoblastoma Protein Sarcoma |
| author_facet |
Fariba Navid John J. Letterio Choh L. Yeung Michiel Pegtel Lee J. Helman |
| author_sort |
Fariba Navid |
| title |
Autocrine Transforming Growth Factor-β Growth Pathway in Murine
Osteosarcoma Cell Lines Associated with Inability to Affect
Phosphorylation of Retinoblastoma Protein |
| title_short |
Autocrine Transforming Growth Factor-β Growth Pathway in Murine
Osteosarcoma Cell Lines Associated with Inability to Affect
Phosphorylation of Retinoblastoma Protein |
| title_full |
Autocrine Transforming Growth Factor-β Growth Pathway in Murine
Osteosarcoma Cell Lines Associated with Inability to Affect
Phosphorylation of Retinoblastoma Protein |
| title_fullStr |
Autocrine Transforming Growth Factor-β Growth Pathway in Murine
Osteosarcoma Cell Lines Associated with Inability to Affect
Phosphorylation of Retinoblastoma Protein |
| title_full_unstemmed |
Autocrine Transforming Growth Factor-β Growth Pathway in Murine
Osteosarcoma Cell Lines Associated with Inability to Affect
Phosphorylation of Retinoblastoma Protein |
| title_sort |
autocrine transforming growth factor-β growth pathway in murine
osteosarcoma cell lines associated with inability to affect
phosphorylation of retinoblastoma protein |
| publisher |
Hindawi Limited |
| series |
Sarcoma |
| issn |
1357-714X 1369-1643 |
| publishDate |
2000-01-01 |
| description |
Purpose. Production of active transforming growth factor-β (TGF-β )
by human osteosarcoma may contribute to malignant progression through mechanisms
that include induction of angiogenesis, immune suppression and autocrine growth
stimulation of tumor cell growth.To study events associated with induction of cell proliferation
by TGF-β , we have evaluated the TGF-β pathway in two murine osteosarcoma cell lines, K7
and K12. |
| url |
http://dx.doi.org/10.1080/13577140020008057 |
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