Small molecule screening in zebrafish: an <it>in vivo </it>approach to identifying new chemical tools and drug leads
<p>Abstract</p> <p>In the past two decades, zebrafish genetic screens have identified a wealth of mutations that have been essential to the understanding of development and disease biology. More recently, chemical screens in zebrafish have identified small molecules that can modula...
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| Format: | Article |
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BMC
2010-06-01
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| Series: | Cell Communication and Signaling |
| Online Access: | http://www.biosignaling.com/content/8/1/11 |
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doaj-9e3b9539374442c08dbf3bcbf161d84c2020-11-25T01:56:01ZengBMCCell Communication and Signaling1478-811X2010-06-01811110.1186/1478-811X-8-11Small molecule screening in zebrafish: an <it>in vivo </it>approach to identifying new chemical tools and drug leadsPatton E ElizabethTemperley Nicholas DGrant Nicola JTaylor Kerrie L<p>Abstract</p> <p>In the past two decades, zebrafish genetic screens have identified a wealth of mutations that have been essential to the understanding of development and disease biology. More recently, chemical screens in zebrafish have identified small molecules that can modulate specific developmental and behavioural processes. Zebrafish are a unique vertebrate system in which to study chemical genetic systems, identify drug leads, and explore new applications for known drugs. Here, we discuss some of the advantages of using zebrafish in chemical biology, and describe some important and creative examples of small molecule screening, drug discovery and target identification.</p> http://www.biosignaling.com/content/8/1/11 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Patton E Elizabeth Temperley Nicholas D Grant Nicola J Taylor Kerrie L |
| spellingShingle |
Patton E Elizabeth Temperley Nicholas D Grant Nicola J Taylor Kerrie L Small molecule screening in zebrafish: an <it>in vivo </it>approach to identifying new chemical tools and drug leads Cell Communication and Signaling |
| author_facet |
Patton E Elizabeth Temperley Nicholas D Grant Nicola J Taylor Kerrie L |
| author_sort |
Patton E Elizabeth |
| title |
Small molecule screening in zebrafish: an <it>in vivo </it>approach to identifying new chemical tools and drug leads |
| title_short |
Small molecule screening in zebrafish: an <it>in vivo </it>approach to identifying new chemical tools and drug leads |
| title_full |
Small molecule screening in zebrafish: an <it>in vivo </it>approach to identifying new chemical tools and drug leads |
| title_fullStr |
Small molecule screening in zebrafish: an <it>in vivo </it>approach to identifying new chemical tools and drug leads |
| title_full_unstemmed |
Small molecule screening in zebrafish: an <it>in vivo </it>approach to identifying new chemical tools and drug leads |
| title_sort |
small molecule screening in zebrafish: an <it>in vivo </it>approach to identifying new chemical tools and drug leads |
| publisher |
BMC |
| series |
Cell Communication and Signaling |
| issn |
1478-811X |
| publishDate |
2010-06-01 |
| description |
<p>Abstract</p> <p>In the past two decades, zebrafish genetic screens have identified a wealth of mutations that have been essential to the understanding of development and disease biology. More recently, chemical screens in zebrafish have identified small molecules that can modulate specific developmental and behavioural processes. Zebrafish are a unique vertebrate system in which to study chemical genetic systems, identify drug leads, and explore new applications for known drugs. Here, we discuss some of the advantages of using zebrafish in chemical biology, and describe some important and creative examples of small molecule screening, drug discovery and target identification.</p> |
| url |
http://www.biosignaling.com/content/8/1/11 |
| work_keys_str_mv |
AT pattoneelizabeth smallmoleculescreeninginzebrafishanitinvivoitapproachtoidentifyingnewchemicaltoolsanddrugleads AT temperleynicholasd smallmoleculescreeninginzebrafishanitinvivoitapproachtoidentifyingnewchemicaltoolsanddrugleads AT grantnicolaj smallmoleculescreeninginzebrafishanitinvivoitapproachtoidentifyingnewchemicaltoolsanddrugleads AT taylorkerriel smallmoleculescreeninginzebrafishanitinvivoitapproachtoidentifyingnewchemicaltoolsanddrugleads |
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