Brucella-Induced Downregulation of lncRNA Gm28309 Triggers Macrophages Inflammatory Response Through the miR-3068-5p/NF-κB Pathway

Brucella-Induced Downregulation of lncRNA Gm28309 Triggers Macrophages Inflammatory Response Through the miR-3068-5p/NF-κB Pathway

ObjectivesThe underlying mechanism of the inflammatory response against Brucellosis caused by Brucella remains poorly understood. This study aimed to determine the role of long non-coding RNAs (lncRNAs) in regulating of inflammatory and anti-Brucella responses.Materials and methodsMicroarray analysi...

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Bibliographic Details
Main Authors: Xingmei Deng, Jia Guo, Zhihua Sun, Laizhen Liu, Tianyi Zhao, Jia Li, Guochao Tang, Hai Zhang, Wenjing Wang, Shuzhu Cao, Dexin Zhu, Tingting Tao, Gang Cao, P. I. Baryshnikov, Chuangfu Chen, Zongsheng Zhao, Lihua Chen, Hui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
LncRNA Gm28309
Brucella
inflammation
miR-3068-5p
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.581517/full

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