Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers

Objective. The aim of the present study was to investigate the transcriptional activity of the GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin-induced diabetes in both untreated and treated with pentoxifylline, as a non-specific blocker of TNF-α.

Bibliographic Details
Main Authors:	Degen Anna S., Krynytska Inna Y., Kamyshnyi Aleksandr M.
Format:	Article
Language:	English
Published:	Sciendo 2020-07-01
Series:	Endocrine Regulations
Subjects:	entero-insular axis mrna diabetes mellitus pentoxifylline
Online Access:	https://doi.org/10.2478/enr-2020-0019

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spelling	doaj-9e248494f2a24267ae224bfea6f6a0092021-09-05T21:00:49ZengSciendoEndocrine Regulations1336-03292020-07-0154316017110.2478/enr-2020-0019enr-2020-0019Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockersDegen Anna S.0Krynytska Inna Y.1Kamyshnyi Aleksandr M.2Zaporizhzhia State Medical University, Zaporizhzhia, UkraineI. Horbachevsky Ternopil National Medical University, Ternopil, UkraineZaporizhzhia State Medical University, Zaporizhzhia, UkraineObjective. The aim of the present study was to investigate the transcriptional activity of the GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin-induced diabetes in both untreated and treated with pentoxifylline, as a non-specific blocker of TNF-α.https://doi.org/10.2478/enr-2020-0019entero-insular axismrnadiabetes mellituspentoxifylline
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Degen Anna S. Krynytska Inna Y. Kamyshnyi Aleksandr M.
spellingShingle	Degen Anna S. Krynytska Inna Y. Kamyshnyi Aleksandr M. Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers Endocrine Regulations entero-insular axis mrna diabetes mellitus pentoxifylline
author_facet	Degen Anna S. Krynytska Inna Y. Kamyshnyi Aleksandr M.
author_sort	Degen Anna S.
title	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_short	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_full	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_fullStr	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_full_unstemmed	Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers
title_sort	changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of tnf-α non-selective blockers
publisher	Sciendo
series	Endocrine Regulations
issn	1336-0329
publishDate	2020-07-01
description	Objective. The aim of the present study was to investigate the transcriptional activity of the GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin-induced diabetes in both untreated and treated with pentoxifylline, as a non-specific blocker of TNF-α.
topic	entero-insular axis mrna diabetes mellitus pentoxifylline
url	https://doi.org/10.2478/enr-2020-0019
work_keys_str_mv	AT degenannas changesinthetranscriptionalactivityoftheenteroinsularaxisgenesinstreptozotocininduceddiabetesandaftertheadministrationoftnfanonselectiveblockers AT krynytskainnay changesinthetranscriptionalactivityoftheenteroinsularaxisgenesinstreptozotocininduceddiabetesandaftertheadministrationoftnfanonselectiveblockers AT kamyshnyialeksandrm changesinthetranscriptionalactivityoftheenteroinsularaxisgenesinstreptozotocininduceddiabetesandaftertheadministrationoftnfanonselectiveblockers
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Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers

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