Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies

Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies

Immune checkpoint blockade is less efficient in patients bearing immunologically ‘cold’ tumors. Oncolytic viruses, which were originally discovered for their ability to preferentially kill malignant cells, can recondition the tumor microenvironment. Supporting this hypothesis, two new studies publis...

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Bibliographic Details
Main Authors: Shashi Gujar, Jonathan G. Pol, Guido Kroemer
Format: Article
Language:English
Published: Taylor & Francis Group 2018-08-01
Series:OncoImmunology
Subjects:
antibodies
antitumor response
antiviral response
ctla-4
immunosurveillance
immunotherapy
immune checkpoint
inflammation and cancer
models of immunostimulation
oncolytic virus
pd-1
pd-l1
therapeutic antibodies
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1442169

Internet

http://dx.doi.org/10.1080/2162402X.2018.1442169

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