Polyhexamethyleneguanidine Phosphate-Induced Cytotoxicity in Liver Cells Is Alleviated by Tauroursodeoxycholic Acid (TUDCA) via a Reduction in Endoplasmic Reticulum Stress

Polyhexamethyleneguanidine Phosphate-Induced Cytotoxicity in Liver Cells Is Alleviated by Tauroursodeoxycholic Acid (TUDCA) via a Reduction in Endoplasmic Reticulum Stress

Polyhexamethyleneguanidine phosphate (PHMG-P) is a widely used polymeric antimicrobial agent known to induce significant pulmonary toxicity. Several studies have reported that the liver also can be a target organ of polyhexamethyleneguanidine (PHMG) toxicity, but the exact effect of this compound on...

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Bibliographic Details
Main Authors: Sou Hyun Kim, Doyoung Kwon, Seunghyun Lee, Sung Hwan Ki, Hye Gwang Jeong, Jin Tae Hong, Yun-Hee Lee, Young-Suk Jung
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
ER stress
PHMG-P
cytotoxicity
liver
tauroursodeoxycholic acid
Online Access:https://www.mdpi.com/2073-4409/8/9/1023

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