The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis

Abstract Osteoarthritis (OA), a most common and highly prevalent joint disease, is closely associated with dysregulated expression and modification of RXRα. However, the role of RXRα in the pathophysiology of OA remains unknown. The present study aimed to investigate whether RXRα modulator, such as...

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Bibliographic Details
Main Authors: Hua Li, Xiaofan Li, Boyu Yang, Junnan Su, Shaofang Cai, Jinmei Huang, Tianfu Hu, Lijuan Chen, Yaping Xu, Yuhang Li
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96517-y