Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

<p>Abstract</p> <p>Background</p> <p>Age-related neurodegenerative diseases share a number of important pathological features, such as accumulation of misfolded proteins as amyloid oligomers and fibrils. Recent evidence suggests that soluble amyloid oligomers and not th...

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Bibliographic Details
Main Authors: Yeung Stephen, Pensalfini Anna, Albay Ricardo, Wu Jessica, Lukacsovich Tamas, Rasool Suhail, Breydo Leonid, Canto Isabel, Kayed Rakez, Head Elizabeth, Marsh J Lawrence, Glabe Charles
Format: Article
Language:English
Published: BMC 2010-12-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/5/1/57