Determination of Budesonide and Sulfasalazine in Water and Wastewater Samples Using DLLME-SFO-HPLC-UV Method

• Main Authors: Marta Hryniewicka, Barbara Starczewska, Agnieszka Gołębiewska
• Format: Article
• Language: English
• Published: MDPI AG 2019-07-01
• Series: Water
• Subjects: budesonide; sulfasalazine; 1-undecanol; DLLME-SFO; HPLC-UV
• Online Access: https://www.mdpi.com/2073-4441/11/8/1581

Dispersive liquid−liquid microextraction based on solidification of floating organic droplet (DLLME-SFO) was applied to isolate budesonide (BUD) and sulfasalazine (SULF) from aqueous samples. The effects of different parameters on the efficiency on the extraction such as type of extrahent and dispersive solvent, ionic strength, pH of sample, and centrifugation time were investigated. Moreover, the influence of foreign substances on a studied process was tested. The calibration curves were recorded. The linearity ranges for BUD and SULF were 0.022−8.611 µg mL^−1 and 0.020−7.968 µg mL^−1 with the limit of detection (LOD) 0.011 µg mL^−1 and 0.012 µg mL^−1, respectively. The enrichment factors (EF) for two analytes were high: for BUD it was 145.7 and for SULF, 119.5. The elaborated procedure was applied for HPLC-UV determination of these analytes in water and wastewater samples.