Phenolic Compounds as Promising Drug Candidates in Tuberculosis Therapy

• Main Authors: Muhamad Harith Mazlun, Siti Fatimah Sabran, Maryati Mohamed, Mohd Fadzelly Abu Bakar, Zunoliza Abdullah
• Format: Article
• Language: English
• Published: MDPI AG 2019-07-01
• Series: Molecules
• Subjects: antimycobacterial; phenolic; phytochemicals; tuberculosis drugs; natural products
• Online Access: https://www.mdpi.com/1420-3049/24/13/2449

Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (MTB) remains one of the deadliest, infectious diseases worldwide. The detrimental effects caused by the existing anti-TB drugs to TB patients and the emergence of resistance strains of <i>M. tuberculosis</i> has driven efforts from natural products researchers around the globe in discovering novel anti-TB drugs that are more efficacious and with less side effects. There were eleven main review publications that focused on natural products with anti-TB potentials. However, none of them specifically emphasized antimycobacterial phenolic compounds. Thus, the current review&#8217;s main objective is to highlight and summarize phenolic compounds found active against mycobacteria from 2000 to 2017. Based on the past studies in the electronic databases, the present review also focuses on several test organisms used in TB researches and their different distinct properties, a few types of in vitro TB bioassay and comparison between their strengths and drawbacks, different methods of extraction, fractionation and isolation, ways of characterizing and identifying isolated compounds and the mechanism of actions of anti-TB phenolic compounds as reported in the literature.