Pharmaceutical Characterization and In Vivo Evaluation of Orlistat Formulations Prepared by the Supercritical Melt-Adsorption Method Using Carbon Dioxide: Effects of Mesoporous Silica Type

Pharmaceutical Characterization and In Vivo Evaluation of Orlistat Formulations Prepared by the Supercritical Melt-Adsorption Method Using Carbon Dioxide: Effects of Mesoporous Silica Type

Orlistat, an anti-obesity drug, has two critical issues—the first is its low efficacy due to low water solubility and the second is side effects such as oily spotting due to its lipase inhibition. The present study was designed to propose a solution using a formulation with mesoporous silica to simu...

Full description

Bibliographic Details
Main Authors: Heejun Park, Kwang-Ho Cha, Seung Hyeon Hong, Sharif Md Abuzar, Seungyeol Lee, Eun-Sol Ha, Jeong-Soo Kim, In-Hwan Baek, Min-Soo Kim, Sung-Joo Hwang
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
orlistat
mesoporous silica
supercritical melt-adsorption
crystallinity
in vivo evaluation
Online Access:https://www.mdpi.com/1999-4923/12/4/333

Similar Items

Similar Items