Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury

Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury

Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating the lipid and lipoprotein metabolism, PPARα also undertakes t...

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Main Authors: Zhixin Gao, Yuan-Hai Li
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2012/738785
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spelling doaj-9de6ba9c1e79455e86ddad5d5420ab482020-11-24T22:30:22ZengHindawi LimitedPPAR Research1687-47571687-47652012-01-01201210.1155/2012/738785738785Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion InjuryZhixin Gao0Yuan-Hai Li1Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaHepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating the lipid and lipoprotein metabolism, PPARα also undertakes the task of organ protection. In this paper, related literature has been summarized and we come to the conclusion that administration of PPARα agonists can strengthen the antioxidant and anti-inflammation defense system by the upregulation of the expression of antioxidant enzymes and inhibition of NF-κB activity. This may provide a potential clinical treatment for hepatic ischemia-reperfusion injury.http://dx.doi.org/10.1155/2012/738785
collection DOAJ
language English
format Article
sources DOAJ
author Zhixin Gao
Yuan-Hai Li
spellingShingle Zhixin Gao
Yuan-Hai Li
Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury
PPAR Research
author_facet Zhixin Gao
Yuan-Hai Li
author_sort Zhixin Gao
title Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury
title_short Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury
title_full Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury
title_fullStr Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury
title_full_unstemmed Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury
title_sort antioxidant stress and anti-inflammation of pparα on warm hepatic ischemia-reperfusion injury
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2012-01-01
description Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating the lipid and lipoprotein metabolism, PPARα also undertakes the task of organ protection. In this paper, related literature has been summarized and we come to the conclusion that administration of PPARα agonists can strengthen the antioxidant and anti-inflammation defense system by the upregulation of the expression of antioxidant enzymes and inhibition of NF-κB activity. This may provide a potential clinical treatment for hepatic ischemia-reperfusion injury.
url http://dx.doi.org/10.1155/2012/738785
work_keys_str_mv AT zhixingao antioxidantstressandantiinflammationofpparaonwarmhepaticischemiareperfusioninjury
AT yuanhaili antioxidantstressandantiinflammationofpparaonwarmhepaticischemiareperfusioninjury
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