LEVEL OF URIC ACID IN BLOOD SERUM OF NEW PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE

• Main Authors: R. Yu. Аbdullaev, O. G. Komissarova, E. S. Chumakova, V. S. Odinet
• Format: Article
• Language: Russian
• Published: NEW TERRA Publishing House 2017-04-01
• Series: Tuberkulez i Bolezni Lëgkih
• Subjects: tuberculosis; uric acid; pyrazinamide; chemotherapy
• Online Access: https://www.tibl-journal.com/jour/article/view/993

The level of uric acid in blood serum was investigated in 134 new patients suffering from multiple drug resistant pulmonary tuberculosis (78 men and 56 women). The tests were performed by admission to hospital and then repeated in 1, 2, 3, 4, 5, 6, 7 and 8 months of treatment. Prior to chemotherapy the increased uric acid level was observed in 28.2% of men and 37.5% of women. During treatment with pyrazinamide uric acid level increased in this category of patients in 1 month after treatment start and further it went down; however it was above normal during the whole course of treatment. Monitoring of uric acid level in the patients with initially normal rates has shown that the primary increase of uric acid was observed during the whole course of chemotherapy (8 months) and more often during the first 2 months of treatment both in men and women.