The Number of Fetal Nephron Progenitor Cells Limits Ureteric Branching and Adult Nephron Endowment

Nephrons, the functional units of the kidney, develop from progenitor cells (cap mesenchyme [CM]) surrounding the epithelial ureteric bud (UB) tips. Reciprocal signaling between UB and CM induces nephrogenesis and UB branching. Although low nephron number is implicated in hypertension and renal dise...

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Bibliographic Details
Main Authors: Cristina Cebrian, Naoya Asai, Vivette D’Agati, Frank Costantini
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714001478