The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma

The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma

Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methy...

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Main Authors: Zhe Li, Jiwei Zhang, Xinyang Liu, Shengli Li, Qifeng Wang, Di Chen, Zhixiang Hu, Tao Yu, Jie Ding, Jinjun Li, Ming Yao, Jia Fan, Shenglin Huang, Qiang Gao, Yingjun Zhao, Xianghuo He
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04006-0
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spelling doaj-9dcb8b8340b24598b29ef3aec8b84b0a2021-05-11T10:21:44ZengNature Publishing GroupNature Communications2041-17232018-04-019111410.1038/s41467-018-04006-0The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinomaZhe Li0Jiwei Zhang1Xinyang Liu2Shengli Li3Qifeng Wang4Di Chen5Zhixiang Hu6Tao Yu7Jie Ding8Jinjun Li9Ming Yao10Jia Fan11Shenglin Huang12Qiang Gao13Yingjun Zhao14Xianghuo He15Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityFudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityLiver Cancer Institute, Zhongshan Hospital, Shanghai Medical College, Fudan UniversityFudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityFudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityFudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityFudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of MedicineFudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of MedicineLiver Cancer Institute, Zhongshan Hospital, Shanghai Medical College, Fudan UniversityFudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityLiver Cancer Institute, Zhongshan Hospital, Shanghai Medical College, Fudan UniversityFudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityFudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Department of Oncology, Shanghai Medical College, Fudan UniversityLong intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methyltransferase PRMT5 by preventing the association of PRMT5 to the E3 ubiquitin ligase CHIP.https://doi.org/10.1038/s41467-018-04006-0
collection DOAJ
language English
format Article
sources DOAJ
author Zhe Li
Jiwei Zhang
Xinyang Liu
Shengli Li
Qifeng Wang
Di Chen
Zhixiang Hu
Tao Yu
Jie Ding
Jinjun Li
Ming Yao
Jia Fan
Shenglin Huang
Qiang Gao
Yingjun Zhao
Xianghuo He
spellingShingle Zhe Li
Jiwei Zhang
Xinyang Liu
Shengli Li
Qifeng Wang
Di Chen
Zhixiang Hu
Tao Yu
Jie Ding
Jinjun Li
Ming Yao
Jia Fan
Shenglin Huang
Qiang Gao
Yingjun Zhao
Xianghuo He
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
Nature Communications
author_facet Zhe Li
Jiwei Zhang
Xinyang Liu
Shengli Li
Qifeng Wang
Di Chen
Zhixiang Hu
Tao Yu
Jie Ding
Jinjun Li
Ming Yao
Jia Fan
Shenglin Huang
Qiang Gao
Yingjun Zhao
Xianghuo He
author_sort Zhe Li
title The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_short The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_full The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_fullStr The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_full_unstemmed The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_sort linc01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-04-01
description Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methyltransferase PRMT5 by preventing the association of PRMT5 to the E3 ubiquitin ligase CHIP.
url https://doi.org/10.1038/s41467-018-04006-0
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