Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular mechanism by which heme enhances processing fidelity.

Bibliographic Details
Main Authors: Alexander C. Partin, Tri D. Ngo, Emily Herrell, Byung-Cheon Jeong, Gary Hon, Yunsun Nam
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01713-y
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spelling doaj-9dc320f8abfd4f8580b4b89fde13f51e2021-05-11T07:21:06ZengNature Publishing GroupNature Communications2041-17232017-11-018111010.1038/s41467-017-01713-yHeme enables proper positioning of Drosha and DGCR8 on primary microRNAsAlexander C. Partin0Tri D. Ngo1Emily Herrell2Byung-Cheon Jeong3Gary Hon4Yunsun Nam5Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical CenterCecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical CenterCecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical CenterCecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical CenterCecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical CenterCecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical CenterDrosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular mechanism by which heme enhances processing fidelity.https://doi.org/10.1038/s41467-017-01713-y
collection DOAJ
language English
format Article
sources DOAJ
author Alexander C. Partin
Tri D. Ngo
Emily Herrell
Byung-Cheon Jeong
Gary Hon
Yunsun Nam
spellingShingle Alexander C. Partin
Tri D. Ngo
Emily Herrell
Byung-Cheon Jeong
Gary Hon
Yunsun Nam
Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
Nature Communications
author_facet Alexander C. Partin
Tri D. Ngo
Emily Herrell
Byung-Cheon Jeong
Gary Hon
Yunsun Nam
author_sort Alexander C. Partin
title Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_short Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_full Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_fullStr Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_full_unstemmed Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_sort heme enables proper positioning of drosha and dgcr8 on primary micrornas
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular mechanism by which heme enhances processing fidelity.
url https://doi.org/10.1038/s41467-017-01713-y
work_keys_str_mv AT alexandercpartin hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas
AT tridngo hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas
AT emilyherrell hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas
AT byungcheonjeong hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas
AT garyhon hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas
AT yunsunnam hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas
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