Dietary Supplementation With the Ketogenic Diet Metabolite Beta-Hydroxybutyrate Ameliorates Post-TBI Aggression in Young-Adult Male Drosophila

Dietary Supplementation With the Ketogenic Diet Metabolite Beta-Hydroxybutyrate Ameliorates Post-TBI Aggression in Young-Adult Male Drosophila

Traumatic brain injury (TBI), caused by repeated concussive head trauma can induce chronic traumatic encephalopathy (CTE), a neurodegenerative disease featuring behavioral symptoms ranging from cognitive deficits to elevated aggression. In a Drosophila model, we used a high-impact trauma device (Kat...

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Bibliographic Details
Main Authors: Derek C. Lee, Krishna Vali, Shane R. Baldwin, Jeffrey N. Divino, Justin L. Feliciano, Jesus R. Fequiere, Mirella A. Fernandez, James C. Frageau, Frank K. Longo, Salaheddine S. Madhoun, Pasquale Mingione V, Timothy R. O’Toole, Maria G. Ruiz, Geoffrey R. Tanner
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Neuroscience
Subjects:
ketogenic diet (KD)
traumatic brain injuries (TBI)
aggression
Drosophila
chronic traumatic encephalopathies (CTE)
KATP channel
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01140/full

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