Gynura procumbens Prevents Chemoresistance through Inhibition MDR1 Expression on MCF-7 Breast Cancer Cell Line and Sensitizes the Cells to Doxorubicin

Gynura procumbens Prevents Chemoresistance through Inhibition MDR1 Expression on MCF-7 Breast Cancer Cell Line and Sensitizes the Cells to Doxorubicin

The long-term exposure of doxorubicin (Dox) causes enhancement in MDR1 expression that leads to breast cancer cell resistance. This protein become a serious problem in cancer treatment and also well-known as negative prognostic factor in breast cancer malignancies. The new approach using natural che...

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Bibliographic Details
Main Authors: Nunuk Aries Nurulita, Edy Meiyanto, Eishou Matsuda, Masashi Kawaichi
Format: Article
Language:English
Published: Universitas Gadjah Mada, Yogyakarta 2012-06-01
Series:Indonesian Journal of Biotechnology
Subjects:
Gynura procumbens
Chemoresistance
MDR1
MCF-7
MCF-7/Dox
Online Access:https://jurnal.ugm.ac.id/ijbiotech/article/view/15998

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