The Genetic Polymorphism of ATP2B1 associated with Essential Hypertension
Objective: The pathogenesis for hypertension is complicated. Except environmental factors, genetic variations are a large part of reasons account for hypertension. With the rapid development of sequencing techniques, genome wide association study (GWAS) provide an effective method for understandi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2019-10-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201910/15.pdf |
| Summary: | Objective: The pathogenesis for hypertension is complicated. Except environmental factors,
genetic variations are a large part of reasons account for hypertension. With the rapid
development of sequencing techniques, genome wide association study (GWAS) provide
an effective method for understanding the complicated genetic backgroundof multifactorial
diseases. More than 150 genes associated with essential hypertension were knew today, of
which, ATP2B1 is most prominent. Whether in Europe or in East Asia, the association between
essential hypertension and ATP2B1 is statistically significant in different people with different
genetic background. Here we reviewed the relationship between genetic polymorphisms of
ATP2B1 and essential hypertension. |
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| ISSN: | 1007-1237 1007-1237 |