Prognostic significance of proinflammatory factors in patients with progressive angina pectoris and type 2 diabetes mellitus

• Main Authors: Olga Leonidovna Barbarash, Aleksey Nikolaevich Sumin, Olesya Evgen'evna Avramenko, Anastasia Vyacheslavovna Osokina, Aleksey Vladimirovich Veremeev
• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2012-12-01
• Series: Сахарный диабет
• Subjects: unstable angina; non-specific inflammation; unfavorable prognosis; diabetes mellitus
• Online Access: https://dia-endojournals.ru/dia/article/viewFile/5536/3334
• ISSN: 2072-0351; 2072-0378

Aims. Our study was aimed to assess the influence of non-specific inflammation and endothelial dysfunction on developmentof cardiovascular events in patients with type 2 diabetes mellitus (T2DM) and progressive angina pectoris. Materials and methods. 140 patients (63 of them were also diabetic) received follow-up for cardiovascular events during12 months after an episode of unstable angina pectoris. Upon hospitalization for acute coronary syndrome analyses wereperformed to assess the degree of systemic inflammation evaluating plasma concentration of pro- and anti-inflammatorymarkers (CRP, fibrinogen, IL-6, -8, -10, TNF-?), as well as blood glucose and glycated haemoglobin HbA1c. Results. TNF-? and IL-6 levels were significantly higher in patients with unfavorable prognosis (p