Acute Metabolic Alkalosis Enhances Response of C3H Mouse Mammary Tumors to the Weak Base Mitoxantrone

Acute Metabolic Alkalosis Enhances Response of C3H Mouse Mammary Tumors to the Weak Base Mitoxantrone

Uptake of weak acid and weak base chemotherapeutic drugs by tumors is greatly influenced by the tumor extracellular/interstitial pH (pHe), the intracellular pH (pHi) maintained by the tumor cells, and by the ionization properties of the drug itself. The acid-outside plasmalemmal pH gradient in tumo...

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Bibliographic Details
Main Authors: Natarajan Raghunand, Brent Mahoney, Robert van Sluis, Brenda Baggett, Robert J Gillies
Format: Article
Language:English
Published: Elsevier 2001-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
tumor pH
drug resistance
sodium bicarbonate
weak base
weak acid
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558601800464

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