Cell-type specific MyD88 signaling is required for intestinal tumor initiation and progression to malignancy

Cell-type specific MyD88 signaling is required for intestinal tumor initiation and progression to malignancy

The signal adapter MyD88, an essential component of Toll-like receptor (TLR) signaling, is important for gut-microbiome interactions. However, its contribution to cancer and its cell-type specific functions are controversially discussed. Therefore, we generated new tissue-specific mouse models and a...

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Bibliographic Details
Main Authors: Anne Holtorf, Anja Conrad, Bernhard Holzmann, Klaus-Peter Janssen
Format: Article
Language:English
Published: Taylor & Francis Group 2018-08-01
Series:OncoImmunology
Subjects:
apc
colorectal cancer
mouse model
toll-like receptors
tumor immunology
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1466770

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