Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction

Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction

Abstract Background Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer’s disease (AD). Epistasis has been considered as one of the main causes of “missing heritability” in AD. Methods We performed genome-wide epista...

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Bibliographic Details
Main Authors: Hui Wang, David A. Bennett, Philip L. De Jager, Qing-Ye Zhang, Hong-Yu Zhang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Association studies in genetics
Gene expression studies
Polygenic risk score
Online Access:https://doi.org/10.1186/s13195-021-00794-8

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