Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.

Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.

Presenilin 1 (PS1) and Presenilin 2 (PS2) are the enzymatic component of the γ-secretase complex that cleaves amyloid precursor protein (APP) to release amyloid beta (Aβ) peptide. PS deficiency in mice results in neuroinflammation and neurodegeneration in the absence of accumulated Aβ. We hypothesiz...

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Bibliographic Details
Main Authors: Suman Jayadev, Amanda Case, Alison J Eastman, Huy Nguyen, Julia Pollak, Jesse C Wiley, Thomas Möller, Richard S Morrison, Gwenn A Garden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3012089?pdf=render

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http://europepmc.org/articles/PMC3012089?pdf=render

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