Association study between matrix metalloproteinase‐3 gene (MMP3) polymorphisms and ankylosing spondylitis susceptibility

• Main Authors: Yong Zhu, Shunan Li, Zhi Huang, Wenhua Xing, Feng Li, Yifeng Da, Jianmin Xue, Manglai Li, Ke Sun, Haiyu Jia, Xuejun Yang
• Format: Article
• Language: English
• Published: Wiley 2019-07-01
• Series: Molecular Genetics & Genomic Medicine
• Subjects: Ankylosing spondylitis (AS); Chinese population; matrix metalloproteinase3 (MMP3); Single nucleotide polymorphisms (SNPs)
• Online Access: https://doi.org/10.1002/mgg3.752

Abstract Background Ankylosing spondylitis (AS) is the second most common cause of inflammatory arthritis worldwide affecting the axial skeleton. Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase‐3 (MMP3) in the development of AS has few been investigated in Chinese population. Methods A total of 362 patients with AS and 362 healthy controls were enrolled in the study. Five SNPs in MMP3 genotypes were identified by Agena MassARRAY. Chi‐squared tests and genetic model were used to evaluate associations. Results rs522616 had a significant risk of AS development compared to those with the TT genotype (p = 0.008). By multiple logistic regression models analysis, in codominant model, rs522616 CT genotypes also had a 1.44‐fold risk (95% CI = 1.06–1.96, p = 0.008) for AS development compared to those with TT genotypes. In recessive model, the CC genotypes was a significantly reduced AS risk for individuals with TT/CT genotype (OR = 0.64; 95% CI = 0.41–0.99, p = 0.040). Conclusion The present study suggests that MMP3 rs522616 polymorphism is associated with AS susceptibility and MMP3 might be a potential diagnostic biomarker for AS. Further independent studies with larger cohorts are warranted to validate our findings in different populations.