Myogenic-specific ablation of Fgfr1 impairs FGF2-mediated proliferation of satellite cells at the myofiber niche but does not abolish the capacity for muscle regeneration

Myogenic-specific ablation of Fgfr1 impairs FGF2-mediated proliferation of satellite cells at the myofiber niche but does not abolish the capacity for muscle regeneration

Skeletal muscle satellite cells (SCs) are Pax7+ myogenic stem cells that reside between the basal lamina and the plasmalemma of the myofiber. In mature muscles, SCs are typically quiescent, but can be activated in response to muscle injury. Depending on the magnitude of tissue trauma, SCs may divide...

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Bibliographic Details
Main Authors: Zipora eYablonka-Reuveni, Maria Elena eDanoviz, Michael ePhelps, Pascal eStuelsatz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Flow Cytometry
Muscle Spindles
Myogenin
skeletal muscle
FGFR1
satellite cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00085/full

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