Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease

Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is a highly prevalent neurodegenerative disorder characterized by pathological hallmarks of beta-amyloid plaque deposits, tau pathology, inflammation, and cognitive decline. Treatment remains a clinical obstacle due to lack of effective therapeutics. Agon...

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Bibliographic Details
Main Authors: Brad T. Casali, Erin G. Reed-Geaghan, Gary E. Landreth
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
Nuclear receptors
RXR
Microgliosis
ABCA1
APOE
Bexarotene
Online Access:http://link.springer.com/article/10.1186/s12974-018-1091-y

Internet

http://link.springer.com/article/10.1186/s12974-018-1091-y

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