The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones

The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones

Chalcones have shown a broad spectrum of biological activities with clinical potential against various diseases. The biological activities are mainly attributed to the presence in the chalcones of the α,β-unsaturated carbonyl system, perceived as a potential Michael acceptor. Chalcones could activat...

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Bibliographic Details
Main Authors: Matheus de Freitas Silva, Letizia Pruccoli, Fabiana Morroni, Giulia Sita, Francesca Seghetti, Claudio Viegas, Andrea Tarozzi
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
chalcones
Nrf2
Keap1
NF-κB
antioxidant activity
anti-inflammatory activity
multi-target activity
Online Access:http://www.mdpi.com/1420-3049/23/7/1803

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