Identification of Important Chemical Features of 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors: Application of Ligand Based Virtual Screening and Density Functional Theory

Identification of Important Chemical Features of 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors: Application of Ligand Based Virtual Screening and Density Functional Theory

11ß-Hydroxysteroid dehydrogenase type1 (11ßHSD1) regulates the conversion from inactive cortisone to active cortisol. Increased cortisol results in diabetes, hence quelling the activity of 11ßHSD1 has been thought of as an effective approach for the treatment of diabetes. Quantitative hypotheses wer...

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Bibliographic Details
Main Authors: Keun Woo Lee, Sundaraganesan Namadevan, Young-Sik Sohn, Chandrasekaran Meganathan, Sugunadevi Sakkiah
Format: Article
Language:English
Published: MDPI AG 2012-04-01
Series:International Journal of Molecular Sciences
Subjects:
11β-hydroxysteroid dehydrogenase
pharmacophore
density function theory
molecular docking
diabetes
virtual screening
Online Access:http://www.mdpi.com/1422-0067/13/4/5138

Internet

http://www.mdpi.com/1422-0067/13/4/5138

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