Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats
Abstract Background Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal s...
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doaj-9d4cbc3595db4805aaf8d8821ba9b3fa2020-11-25T03:59:05ZengBMCBMC Endocrine Disorders1472-68232020-08-012011810.1186/s12902-020-00603-7Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese ratsAlejandra Martínez Coria0Norma Angélica Estrada-Cruz1María Inés Pérez Ordoñez2Daniel H. Montes-Cortes3Leticia Manuel-Apolinar4Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro SocialUnidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro SocialUnidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro SocialDepartamento de Urgencias Adultos, Hospital General Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social/Coordinación de Enseñanza e Investigación, Hospital Regional 1° de Octubre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del EstadoUnidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro SocialAbstract Background Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats. Methods Sprague Dawley rats (250 ± 5 g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities. Results The body weight in the Ob group was increased compared to that in the control group, (p < 0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p < 0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p < 0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities. Conclusion Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints.http://link.springer.com/article/10.1186/s12902-020-00603-7ObesityEndothelial dysfunctionICAM-1Echographic analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alejandra Martínez Coria Norma Angélica Estrada-Cruz María Inés Pérez Ordoñez Daniel H. Montes-Cortes Leticia Manuel-Apolinar |
spellingShingle |
Alejandra Martínez Coria Norma Angélica Estrada-Cruz María Inés Pérez Ordoñez Daniel H. Montes-Cortes Leticia Manuel-Apolinar Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats BMC Endocrine Disorders Obesity Endothelial dysfunction ICAM-1 Echographic analysis |
author_facet |
Alejandra Martínez Coria Norma Angélica Estrada-Cruz María Inés Pérez Ordoñez Daniel H. Montes-Cortes Leticia Manuel-Apolinar |
author_sort |
Alejandra Martínez Coria |
title |
Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats |
title_short |
Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats |
title_full |
Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats |
title_fullStr |
Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats |
title_full_unstemmed |
Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats |
title_sort |
echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats |
publisher |
BMC |
series |
BMC Endocrine Disorders |
issn |
1472-6823 |
publishDate |
2020-08-01 |
description |
Abstract Background Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats. Methods Sprague Dawley rats (250 ± 5 g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities. Results The body weight in the Ob group was increased compared to that in the control group, (p < 0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p < 0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p < 0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities. Conclusion Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints. |
topic |
Obesity Endothelial dysfunction ICAM-1 Echographic analysis |
url |
http://link.springer.com/article/10.1186/s12902-020-00603-7 |
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