Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Abstract Background Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal s...

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Main Authors: Alejandra Martínez Coria, Norma Angélica Estrada-Cruz, María Inés Pérez Ordoñez, Daniel H. Montes-Cortes, Leticia Manuel-Apolinar
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Endocrine Disorders
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12902-020-00603-7
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spelling doaj-9d4cbc3595db4805aaf8d8821ba9b3fa2020-11-25T03:59:05ZengBMCBMC Endocrine Disorders1472-68232020-08-012011810.1186/s12902-020-00603-7Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese ratsAlejandra Martínez Coria0Norma Angélica Estrada-Cruz1María Inés Pérez Ordoñez2Daniel H. Montes-Cortes3Leticia Manuel-Apolinar4Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro SocialUnidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro SocialUnidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro SocialDepartamento de Urgencias Adultos, Hospital General Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social/Coordinación de Enseñanza e Investigación, Hospital Regional 1° de Octubre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del EstadoUnidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro SocialAbstract Background Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats. Methods Sprague Dawley rats (250 ± 5 g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities. Results The body weight in the Ob group was increased compared to that in the control group, (p < 0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p < 0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p < 0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities. Conclusion Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints.http://link.springer.com/article/10.1186/s12902-020-00603-7ObesityEndothelial dysfunctionICAM-1Echographic analysis
collection DOAJ
language English
format Article
sources DOAJ
author Alejandra Martínez Coria
Norma Angélica Estrada-Cruz
María Inés Pérez Ordoñez
Daniel H. Montes-Cortes
Leticia Manuel-Apolinar
spellingShingle Alejandra Martínez Coria
Norma Angélica Estrada-Cruz
María Inés Pérez Ordoñez
Daniel H. Montes-Cortes
Leticia Manuel-Apolinar
Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats
BMC Endocrine Disorders
Obesity
Endothelial dysfunction
ICAM-1
Echographic analysis
author_facet Alejandra Martínez Coria
Norma Angélica Estrada-Cruz
María Inés Pérez Ordoñez
Daniel H. Montes-Cortes
Leticia Manuel-Apolinar
author_sort Alejandra Martínez Coria
title Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats
title_short Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats
title_full Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats
title_fullStr Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats
title_full_unstemmed Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats
title_sort echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats
publisher BMC
series BMC Endocrine Disorders
issn 1472-6823
publishDate 2020-08-01
description Abstract Background Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats. Methods Sprague Dawley rats (250 ± 5 g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities. Results The body weight in the Ob group was increased compared to that in the control group, (p < 0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p < 0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p < 0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities. Conclusion Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints.
topic Obesity
Endothelial dysfunction
ICAM-1
Echographic analysis
url http://link.springer.com/article/10.1186/s12902-020-00603-7
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