Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
Asthma is a common allergic airway disease with significant inter-individual heterogeneity. Here, Olafsdottir et al. report a genome-wide meta-analysis of two large population-based cohorts to identify sequence variants that associate with asthma risk and perform follow-up functional analyses on a p...
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Nature Publishing Group
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-14144-8 |
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doaj-9d4c023806ed4deaa904e9b46d6dc5a92021-05-11T08:54:04ZengNature Publishing GroupNature Communications2041-17232020-01-0111111110.1038/s41467-019-14144-8Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesisThorunn A. Olafsdottir0Fannar Theodors1Kristbjorg Bjarnadottir2Unnur Steina Bjornsdottir3Arna B. Agustsdottir4Olafur A. Stefansson5Erna V. Ivarsdottir6Jon K. Sigurdsson7Stefania Benonisdottir8Gudmundur I. Eyjolfsson9David Gislason10Thorarinn Gislason11Steinunn Guðmundsdóttir12Arnaldur Gylfason13Bjarni V. Halldorsson14Gisli H. Halldorsson15Thorhildur Juliusdottir16Anna M. Kristinsdottir17Dora Ludviksdottir18Bjorn R. Ludviksson19Gisli Masson20Kristjan Norland21Pall T. Onundarson22Isleifur Olafsson23Olof Sigurdardottir24Lilja Stefansdottir25Gardar Sveinbjornsson26Vinicius Tragante27Daniel F. Gudbjartsson28Gudmar Thorleifsson29Patrick Sulem30Unnur Thorsteinsdottir31Gudmundur L. Norddahl32Ingileif Jonsdottir33Kari Stefansson34deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.Department of Medicine, Landspitali, The National University Hospital of IcelanddeCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.The Laboratory in Mjodd, RAMThe Medical Center MjoddFaculty of Medicine, School of Health Sciences, University of IcelanddeCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.Faculty of Medicine, School of Health Sciences, University of IcelandFaculty of Medicine, School of Health Sciences, University of IcelanddeCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.Faculty of Medicine, School of Health Sciences, University of IcelandDepartment of Clinical Biochemistry, Landspitali, The National University Hospital of IcelandFaculty of Medicine, School of Health Sciences, University of IcelanddeCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.deCODE genetics/Amgen, Inc.Asthma is a common allergic airway disease with significant inter-individual heterogeneity. Here, Olafsdottir et al. report a genome-wide meta-analysis of two large population-based cohorts to identify sequence variants that associate with asthma risk and perform follow-up functional analyses on a protective loss-of-function variant in TNFRSF8.https://doi.org/10.1038/s41467-019-14144-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Thorunn A. Olafsdottir Fannar Theodors Kristbjorg Bjarnadottir Unnur Steina Bjornsdottir Arna B. Agustsdottir Olafur A. Stefansson Erna V. Ivarsdottir Jon K. Sigurdsson Stefania Benonisdottir Gudmundur I. Eyjolfsson David Gislason Thorarinn Gislason Steinunn Guðmundsdóttir Arnaldur Gylfason Bjarni V. Halldorsson Gisli H. Halldorsson Thorhildur Juliusdottir Anna M. Kristinsdottir Dora Ludviksdottir Bjorn R. Ludviksson Gisli Masson Kristjan Norland Pall T. Onundarson Isleifur Olafsson Olof Sigurdardottir Lilja Stefansdottir Gardar Sveinbjornsson Vinicius Tragante Daniel F. Gudbjartsson Gudmar Thorleifsson Patrick Sulem Unnur Thorsteinsdottir Gudmundur L. Norddahl Ingileif Jonsdottir Kari Stefansson |
| spellingShingle |
Thorunn A. Olafsdottir Fannar Theodors Kristbjorg Bjarnadottir Unnur Steina Bjornsdottir Arna B. Agustsdottir Olafur A. Stefansson Erna V. Ivarsdottir Jon K. Sigurdsson Stefania Benonisdottir Gudmundur I. Eyjolfsson David Gislason Thorarinn Gislason Steinunn Guðmundsdóttir Arnaldur Gylfason Bjarni V. Halldorsson Gisli H. Halldorsson Thorhildur Juliusdottir Anna M. Kristinsdottir Dora Ludviksdottir Bjorn R. Ludviksson Gisli Masson Kristjan Norland Pall T. Onundarson Isleifur Olafsson Olof Sigurdardottir Lilja Stefansdottir Gardar Sveinbjornsson Vinicius Tragante Daniel F. Gudbjartsson Gudmar Thorleifsson Patrick Sulem Unnur Thorsteinsdottir Gudmundur L. Norddahl Ingileif Jonsdottir Kari Stefansson Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis Nature Communications |
| author_facet |
Thorunn A. Olafsdottir Fannar Theodors Kristbjorg Bjarnadottir Unnur Steina Bjornsdottir Arna B. Agustsdottir Olafur A. Stefansson Erna V. Ivarsdottir Jon K. Sigurdsson Stefania Benonisdottir Gudmundur I. Eyjolfsson David Gislason Thorarinn Gislason Steinunn Guðmundsdóttir Arnaldur Gylfason Bjarni V. Halldorsson Gisli H. Halldorsson Thorhildur Juliusdottir Anna M. Kristinsdottir Dora Ludviksdottir Bjorn R. Ludviksson Gisli Masson Kristjan Norland Pall T. Onundarson Isleifur Olafsson Olof Sigurdardottir Lilja Stefansdottir Gardar Sveinbjornsson Vinicius Tragante Daniel F. Gudbjartsson Gudmar Thorleifsson Patrick Sulem Unnur Thorsteinsdottir Gudmundur L. Norddahl Ingileif Jonsdottir Kari Stefansson |
| author_sort |
Thorunn A. Olafsdottir |
| title |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_short |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_full |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_fullStr |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_full_unstemmed |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_sort |
eighty-eight variants highlight the role of t cell regulation and airway remodeling in asthma pathogenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
Asthma is a common allergic airway disease with significant inter-individual heterogeneity. Here, Olafsdottir et al. report a genome-wide meta-analysis of two large population-based cohorts to identify sequence variants that associate with asthma risk and perform follow-up functional analyses on a protective loss-of-function variant in TNFRSF8. |
| url |
https://doi.org/10.1038/s41467-019-14144-8 |
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